Progress Update: One-year funding 9/2013-8/2014 The main goal of this proposal is to compare changes in the abundance of a group of molecules that have been recently discovered and named “microRNAs” in pilocytic astrocytoma (PA), the most frequent low grade glioma in children. MicroRNAs are of very small size and…
Progress Update: 9/2013-8/2015 Medulloblastoma (MB) is a highly malignant brain tumor affecting predominantly children. MB arises from granular progenitors that after cerebella development do not respond to cellular cues to stop functioning, resulting in them becoming cancer stem/progenitor cells (CSC) that drive tumor progression. Such CSCs are thought to be…
Progress Update: 9/2012-8/2014 We have completed the initial set of studies to examine the role of MPS1 in controlling medulloblastoma cell division and validated a therapeutic target. We demonstrated that MPS1 is critical for cell division of tumor cells and both genetic and chemi-cal inhibition of MPS1. Several 1st generation…
Progress Update from 1st year: 8/1/2014-7/30/2016 Millions of cells are formed every day in the developing brain of children. Medulloblastoma, the most common and ag-gressive form of pediatric brain tumor, occurs when the proliferation of cells in the cerebellum becomes uncontrolled, The Notch path-way is a key mechanism that governs…
Progress Update from 2nd year: 9/2012-8/2014 The Childhood Brain Tumor Foundation funded project, Novel Agent for Pediatric Glioblastomas (pGBMs), headed by Dr. Rheal Towner at the Oklahoma Medical Research Foundation, is assessing a novel agent, Oklahoma Nitrone 007 (OKN-007), in pre-clinical mouse models for pediatric glioblastomas (pGBs). Patient-derived cells, which…
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