One of the goals of pediatric cancer treatment is deploying personalized medicine. Treating each patient and each tumor, with exactly the right type of therapy to maximize killing of tumor cells and minimize side effects to patients is the objective. Initially, brain tumors were classified by their appearance under the…
When a child is diagnosed with cancer it is devastating for the entire family. The good news is that cure rates for childhood cancer are at nearly 80 percent thanks to ongoing research that has improved the diagnosis and treatment of pediatric cancers. There are more than 250,000 childhood cancer…
For over 50 years, the field of cancer therapy has been dominated by the concept that the tumor must be the selected target of the chemotherapy delivered. Therefore, any drug with the ability to directly kill tumor cells in the laboratory was by definition a candidate for use as chemotherapy…
by Roger J. Packer, M.D., Founding and Sr. Scientific Advisor, CBTF-MDSignificant progress has been made in the management of some forms of childhood brain tumors. However, for children with malignant gliomas including those of the cerebral cortex, diencephalon, brain stem, or cerebellum, progress has been frustratingly slow. The majority of…
Current diagnostic and therapeutic monitoring studies are significantly limited in their ability to accurately characterize brain tumor biology and response to therapy. With the majority of CNS tumors, a crucial need exists to develop a means to identify tumor markers that can be used to:

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