Clinical and biological relevance of PI3K/AKT/mTOR pathway activation in pilocytic astrocytoma Fausto J. Rodriguez M.D., Johns Hopkins School of Medicine (Report from funding, 2011-2012) This study has been published in two journals.   Pilocytic astrocytomas (PA) are low grade neoplasms that represent the most frequent gliomas in children and your…
The short and long-term effects of biological agents on oligodendrocyte lineage and progenitor cells in the developing brain PI:  Joseph Scafidi, DO – Children’s Research Institute, Washington, DC (update on progress)  Grant duration, Aug. 2011--Sept. 2013   The brain of children is subject to rapid growth and development. White matter…
Sarah  Rush, University of Colorado Summary (2012) :  Research update generated from program CBTF provided support for Pediatric pilocytic and pilomyxoid astrocytomas are slow growing and amenable to surgical cure if located in a favorable place. However, a significant number of children (> 55 %) will eventually suffer from tumor progression.…
PI:  Joseph Scafidi, DO – Children’s Research Institute, Washington, DC (update on progress)  Grant duration, Aug. 2011--Sept. 2013  The brain of children is subject to rapid growth and development. White matter is the part of the brain that is vital for communication and processing of information. White matter comprises nearly…
PI: Lionel Chow, Cincinnati Children’s Hospital Medical Center (report, grant duration 2011-2013)  Children who develop high-grade glioma (HGG) have a very poor prognosis. New and more effective treatment options are desperately needed to improve patient survival and quality of life. In order to better understand how these tumors grow, we…

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