Katherine E. Warren, MD

Katherine E. Warren, MD Katherine E. Warren, MD

Dr. Warren received her B.S., in medical technology in 1982 and her M.D., from Tufts University School of Medicine in 1990. She completed a residency in pediatrics at Children's National Medical Center, followed by a fellowship in pediatric oncology at the National Cancer Institute. She is board certified in pediatric hematology/oncology. Her research interests include performance of clinical trials, particularly in children with tumors of the central nervous system, non-invasive evaluation/imaging of the brain, and neurotoxicity resulting from tumors and their treatment.

Cancer of the central nervous system (CNS) is the leading cause of death from solid tumors in the pediatric population. For some types of CNS malignancies, such as diffuse intrinsic pontine glioma (DIPG) and recurrent malignant glioma, no significant improvement in survival has been demonstrated over the past three decades. The approach to treatment has not changed substantially, despite increasing knowledge of tumor biology. The goal of Dr. Warren's research is to establish new therapeutic paradigms based on pharmacokinetic and biologic rationale to improve both survival and quality of life for children with CNS tumors.

Dr. Warren's strategy entails a multifaceted approach.

  1. Experimental therapeutics and extensive noninvasive analysis of individual patients, including multiparametric imaging
  2. Utilization of a nonhuman primate model to study CNS pharmacology of agents and alternate delivery methods
  3. Identification of intratumor genomic alterations that encode potentially druggable targets

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