Tobey J. MacDonald, MD

Tobey J. MacDonald, MD Tobey J. MacDonald, MD

Associate Professor Pediatrics
Director, Pediatric Neuro-Oncology Program

Following his training in pediatrics, pediatric hematology-oncology and neuro-oncology, Dr. MacDonald has built a career that encompasses clinical, basic and translational research of childhood brain tumors. He has received continuous NIH-sponsored funding support for his research efforts for the past 9 years, which has focused on identification of molecular therapeutic targets of perdiatric brain tumors. Having pioneered the use of microarray technology for the study of pediatric medulloblastoma and astrocytoma, and discovering that the platelet-derived growth factor receptor (PDGFR) is active and over-produced by metastatic tumors and tumors demonstrating more malignant characteristics, respectively, he is now working to translate these and other novel findings to innovative treatments for children with brain tumors.

Before joining the Aflac Cancer Center to direct the Pediatric Neuro-Oncology Program in September 2009, Dr. MacDonald served as the Clinical Director of Neuro-oncology at Children’s National Medical Center from 1998-2009 and served as Chair of Infant Brain Tumors for the NIH-sponsored Pediatric Brain Tumor Consortium (PBTC) as well as Co-Chair of the PBTC Biology and Angiogenesis Committees since the group’s inception in 1999. In addition to serving on numerous clinical trial committees within PBTC and the Children’s Oncology Group, most prominently as Principal Investigator of the completed Phase I and currently ongoing Phase II study of cilengitide, which he helped to develop from bench-to-bedside, Dr. MacDonald was the institutional Principal Investigator for over 26 clinical trials conducted through PBTC.

One of his additional passions is training the next generation of pediatric scientists, and over the past 10 years, he has mentored 14 students, from undergraduate to graduate and medical, and 9 post-doctoral fellows, the majority of which are now currently conducting oncology research of their own.

Click here to view Dr. MacDonald's full biography.

Thanks to Our Sponsors